Pharmacological Reference · Research Compendium

Peptide Knowledge Graph

Tap any peptide card → profile loads below (mobile) or right panel (desktop)  ·  C = central  ·  P = peripheral  ·  B = both
GH Secretagogues
Healing / Recovery
Fat / Metabolic
Cognitive / Neuroprotective
Central Action
Peripheral Action
Limited Safety Data
Category 01
Growth Hormone Secretagogues
Stimulate endogenous GH release via GHRH receptor or ghrelin receptor pathways. Preserve pulsatile GH secretion.
Sermorelin
GRF 1–29
C
Clinical FDA Approved (historic)
GHRH analog · pituitary stimulation · pulsatile GH preservation
CJC-1295
Modified GRF 1–29 / DAC-GRF
C
Experimental Research Only
Long-acting GHRH analog · DAC linkage extends half-life · blunts GH pulsatility
Ipamorelin
NNC 26-0161
B
Experimental Research Only
Selective GHSR agonist · minimal cortisol/prolactin · clean GH pulse
GHRP-2
Pralmorelin
B
Clinical Approved (JP/select)
Potent GHSR agonist · significant GH pulse · cortisol/prolactin side effects
GHRP-6
His-DTrp-Ala-Trp-DPhe-Lys-NH₂
B
Experimental Research Only
GHSR agonist · strong hunger stimulation · GH + cortisol + prolactin rise
Hexarelin
Examorelin
B
Clinical ⚠ Desensitization
Most potent GHSR agonist · cardioprotective data · rapid receptor desensitization
MK-677
Ibutamoren · Nutrobal
B
Clinical Not Approved ⚠ Oral non-peptide
Oral ghrelin mimetic · sustained GH/IGF-1 elevation · insulin resistance risk
Tesamorelin
Egrifta · TH9507
C
Clinical FDA Approved
Stabilised GHRH analog · visceral fat reduction · HIV lipodystrophy indication
Category 02
Healing & Recovery Peptides
Tissue repair, collagen synthesis, anti-inflammatory, and cytoprotective mechanisms. Variable evidence base.
BPC-157
Body Protection Compound
B
Experimental Research Only ⚠ Limited human data
Angiogenesis · tendon/ligament repair · gut mucosal healing · dopaminergic modulation
TB-500
Thymosin Beta-4 fragment
P
Experimental WADA Banned ⚠ Limited human data
Actin-binding · cell migration · tissue regeneration · anti-inflammatory
Thymosin α1
Zadaxin · Tα1
P
Clinical Approved (select countries)
Immune modulation · T-cell differentiation · antiviral · hepatitis B/C clinical use
LL-37
Cathelicidin · hCAP18
P
Experimental Research Only
Antimicrobial · wound healing · immunomodulatory · endogenous host defense peptide
GHK-Cu
Copper Peptide · Glycyl-L-histidyl-L-lysine
P
Experimental Cosmetic approved (topical)
Collagen/elastin synthesis · angiogenesis · antioxidant gene activation · skin remodelling
SS-31
Elamipretide · MTP-131
P
Clinical Phase III (cardiac) ⚠ Mitochondria-targeted
Cardiolipin binding · mitochondrial membrane stabilisation · ROS reduction · cardiac protection
Category 03
Fat Loss & Metabolic Peptides
Lipolytic, appetite-modulating, and metabolic rate-enhancing mechanisms. Includes melanocortin and adipokine pathways.
AOD-9604
Tyr-hGH177–191
P
Clinical Not Approved (obesity)
C-terminal hGH fragment · β3-adrenoceptor · lipolysis without IGF-1 effects
HGH Frag 176–191
Modified GH Fragment
P
Experimental Research Only
Isolated lipolytic GH region · adipocyte fat breakdown · no anabolic/diabetogenic effects claimed
Melanotan II
MT-II · Afamelanotide analog
C
Experimental Research Only ⚠ High risk profile
MC1R/MC3R/MC4R agonist · tanning · appetite suppression · sexual function · significant side effects
Semaglutide
Ozempic · Wegovy · Rybelsus
B
Clinical FDA Approved
GLP-1 receptor agonist · satiety signalling · insulin sensitisation · 15–20% weight reduction
Tirzepatide
Mounjaro · Zepbound
B
Clinical FDA Approved
Dual GLP-1 / GIP agonist · superior weight loss to GLP-1 alone · metabolic syndrome
5-Amino-1MQ
NNMT inhibitor peptide
P
Experimental Research Only ⚠ Minimal human data
NNMT inhibition → NAD+ availability → adipocyte metabolic reprogramming
Category 04
Cognitive & Neuroprotective Peptides
CNS-active peptides affecting neuroplasticity, neurotransmission, neuroprotection, and BDNF signalling.
Semax
Met-Glu-His-Phe-Pro-Gly-Pro
C
Clinical Approved (Russia)
ACTH/MSH analog · BDNF upregulation · neuroprotection · stroke / cognitive clinical use
Selank
Tuftsin analog · TP-7
C
Clinical Approved (Russia)
Anxiolytic · GABAergic modulation · BDNF/NGF · enkephalin stabilisation · no dependence
Dihexa
PNB-0408 · N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
C
Experimental Research Only ⚠ Very limited safety data
HGF/MET pathway · synaptogenesis · potent pro-cognitive · Alzheimer's models
Epithalon
Epitalon · Tetrapeptide AEDG
B
Experimental Research Only
Telomerase activation · pineal gland support · melatonin regulation · anti-aging claims
Pinealon
EDR · Glu-Asp-Arg
C
Experimental Research Only
Pineal / CNS peptide bioregulator · antioxidant · neuroprotection · sleep quality
PT-141
Bremelanotide · Vyleesi
C
Clinical FDA Approved
MC3R/MC4R agonist · central sexual arousal · CNS dopaminergic pathway · hypoactive sexual desire
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Shared Pathways, Mechanisms & Risk Clusters
GH Axis / IGF-1 Signalling Network
Sermorelin CJC-1295 Ipamorelin GHRP-2 GHRP-6 Hexarelin MK-677 Tesamorelin
BDNF / Neuroplasticity Upregulation
Semax Selank Dihexa BPC-157
Melanocortin Receptor Family (MC1R–MC4R)
Melanotan II PT-141 AOD-9604 (indirect)
Angiogenesis / Tissue Repair Cluster
BPC-157 TB-500 GHK-Cu LL-37 Hexarelin (cardiac)
GLP-1 / Incretin Metabolic Axis
Semaglutide Tirzepatide (+ GIP)
⚠ Limited Human Safety Data
BPC-157 TB-500 Dihexa Melanotan II 5-Amino-1MQ Pinealon CJC-1295
Telomere / Anti-Aging / Longevity Claims
Epithalon Pinealon GHK-Cu SS-31 Semax
Insulin Resistance / Glucose Disruption Risk
MK-677 CJC-1295 (chronic) GHRP-2 (chronic) Melanotan II
PHARMACOLOGICAL REFERENCE ONLY. This knowledge graph is produced for educational and scientific literacy purposes. No information herein constitutes medical advice, clinical guidance, or endorsement of use. Many compounds listed are unscheduled research chemicals with no approved human indications; others are prescription-only or WADA-prohibited. Human safety data is absent or severely limited for the majority of entries. All use should be under qualified medical supervision with appropriate monitoring.